Wait, the Duchess of Windsor had this? Or was it just a nasty rumour made up about her?
Androgen insensitivity syndrome (AIS) is when a person who is genetically male (has one X and one Y chromosome) is resistant to male hormones called androgens. As a result, the person has some or all of the physical characteristics of a woman, despite having the genetic makeup of a man.
I think QEI's issues were more that she was quite high-ranking and perhaps didn't want to marry who was "acceptable" at the time. Also, didn't she take a lover?
And there IS a difference in being infertile (which can occur from many different things) and having this AIS thing.